Sildenafil (ABHIGRA) 100 mg tablet is an inhibitor of phosphodiesterase-5 (PDE5) enzyme, which is primarily used to treat erectile dysfunction and pulmonary hypertension.
Sildenafil is a specific and effective inhibitor of cyclic guanosine monophosphate (cGMP) type 5 (PDE5) phosphodiesterase enzyme in the corpus cavernosum that induces pulmonary vascular smooth muscle cell relaxation. It replenishes reduced erectile capacity by raising blood flow to the penis; Sildenafil also requires sexual stimulation to achieve its pharmacological effects.
Abhigra
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Effect of the potency agent
Abhigra 100mg is used primarily to treat erectile dysfunction (impotence). The active ingredient ensures that an erection can be maintained longer. It has no lust-increasing effect and does not provide for an erection by itself. Rather, Abhigra 100mg improves men’s ability to respond to sexual arousal with an erection. Without a sexual stimulation, however, no erection is triggered.
The drug is just like tadalafil or vardenafil to the group of PDE-5 inhibitors, which have a vasodilator effect. This effect is based on the inhibition of the enzyme phosphodiesterase-5. By inhibiting the enzyme, the blood vessels in the penis relax. This facilitates the influx of blood and the erection of an erection.
Since 2006, Abhigra 100mg has also been approved as a sexual enhancer for the treatment of pulmonary hypertension (pulmonary hypertension). Again, his vasodilator effect plays a crucial role in the treatment.
Abhigra 100mg Side Effects
As with most other medications, sildenafil intake is associated with side effects. These are usually mild to moderate and will fade away after a while. For a complete list of all side effects of the drug, please refer to the package leaflet of your medication.
After taking Abhigra 100mg, the following symptoms may occur:
- a headache
- facial flushing
- stomach discomfort such as nausea, vomiting and diarrhea
- sniff
- vision problems
- dizziness
- muscle and back pain
- palpitation
- hearing impairment
- a lowered reaction
- a permanent erection
In very rare cases, a circulatory disorder of the optic nerve head (anterior ischemic optic neuropathy) was observed after ingestion. This can lead to permanent visual damage or even blindness. Whether the disorder is in a causal relationship with the intake of the drug is still unclear. If you are taking the medicine and have a decrease in vision, contact your doctor immediately and stop taking any more pills.
Abhigra 100mg Dosage
Abhigra 100mg is available in doses of 25, 50 and 100 milligrams and is administered orally.
- Normal tablets should be swallowed whole with some liquid.
- Chewable tablets are first chewed and then swallowed.
- Orodispersible tablets are placed on the tongue and swallowed only after dissolution.
How high the dose to be taken should be with you, your doctor will determine individually. In addition to the individual effectiveness and tolerability of the drug also present underlying diseases play a role. Irrespective of this, it should never be exceeded a daily dose of 100 milligrams.
The effect of the tablet begins about 30 to 60 minutes after ingestion. A luscious, greasy meal may delay the onset of action. After the effect starts, it will last for about four to five hours.
Contraindications: Caution in coronary heart disease
Abhigra 100mg must not be used concomitantly with medications containing nitrates and nitric oxide donors (for example, molsidomine). Otherwise, it can lead to a significant increase in the effectiveness of these drugs.
It should also be noted that patients with coronary heart disease should take the drug only after consulting their doctor. For them, the stress of intercourse can increase the risk of overuse of the circulation. Likewise, the use is contraindicated in severe liver damage and an allergy to the drug.
In addition, Abhigra 100mg should only be taken with particular care in the following conditions: leukemia, peptic ulcer, multiple myeloma, sickle cell anemia, blood clotting disorder. Likewise, if you have a disease or deformity of your penis, you should consult your doctor before taking it.
Interactions with other drugs
Taking sildenafil may result in a number of drug-drug interactions. Affected are primarily drugs that are metabolized with the participation of the same enzymes as the power means:
- ketoconazole
- itraconazole
- erythromycin
- cimetidine
- ritonavir
- saquinavir
Interactions with alpha-blockers may also interact: in some cases, side effects such as drowsiness and dizziness have occurred. However, this can usually be prevented by increasing the time between receipts.
Diltiazem - has anti-anginal, antiarrhytmic and hypotensive effects. Reduces the intracellular maintenance of Ca2+ in cardiomyocytes and cells of smooth muscles of blood vessels, reduces heart rate, shows insignificant negative inotropic effect, improves a coronary, brain and renal blood flow.
Cialis is a latest medicine for treatment of disturbances of erection at men. Cialis feature is its high-speed performance (30 minutes) and a long-term effect (up to 36 hours). In this regard you can choose the moment which is most suitable for sexual intercourse, having accepted a drug in advance. It is possible to take Cialis in the morning and to be ready even next day. Active ingredient - Tadalafil, the recommended dosage - 20 mg.
Cialis Oral Jelly (Orange) - a new formula of Cialis which you can have, without washing down with water. Against background of ordinary drug it differs in increased influence speed. It is prescribed for improvement of sexual endurance of men during intimate proximity. It simplifies the excitative process of penis and strengthens erection. Noticeably increases duration of sexual intercourse. Besides, the drug possesses a pleasant orange flavor.
A peripheral vasodilator, blocks postsynaptic alpha1-adrenergic receptors and prevents the vasoconstrictive influence of catecholamines. It reduces pressure in the pulmonary veins and the right atrium significantly, it also reduces pulmonary vascular resistance moderately. The drug therapeutic indications include: arterial hypertension; CHF (in combination therapy), Raynaud's syndrome and disease, pheochromocytoma, peripheral vascular spasm on the background of poisoning with ergot alkaloids. Prostatic hyperplasia
Co-Amoxiclav - co-formulated antibacterial agent, combine of bactericidal antibiotic of a broad spectrum of activity, from a group of semi-synthetic penicillin - Amoxicillin and Betalactamase inhibitor.
Antidepressant. Strengthens the central adrenergic and serotonergic transfer. Used for the treatment of depressions including anhedonia, psychomotor retardation, insomnia, early awakening, weight loss, loss of interest in life, suicidal thoughts and mood swings.
Glucotrol peroral hypoglycemic medicine. It is taken at a diabetes mellitus of type 2 (at inefficiency of dietotherapy). It has pancreatic and extra pancreatic effects. Stimulates secretion of insulin by reductions of the threshold of irritation with glucose of beta cells of pancreas, increases sensitivity to insulin and extent of its linkng with target cells, increases insulin release, strengthens influence of insulin on glucose absorption by muscles and liver, brakes lipolysis in fatty tissue.
Lisinopril is an antihypertensive, vasodilating, cardioprotective drug, an ACE inhibitor that is used to treat hypertension, heart failure, acute myocardial infarction, diabetic nephropathy.
Zudena is another representative of the PDE5 inhibitors ubiquitously used in contemporary urology. It is commonly used for the therapy and prevention of erectile dysfunction. The pills contain udenafil – a reverse inhibitor of the phosphodiesterase-5, which is responsible for filling the penis with blood. This active ingredient has a range of recently introduced advantages the most notable of which are more rapid absorption (30-60 minutes) and increased half-life (starting from 10 to 12 hours, which leads to a 24-hour period of activity). The medicine may be prescribed not only for symptomatic but also for a long-term treatment.
Cialis Super Active is a generic drug, against erectile dysfunction, containing 20 mg of tadalafil. The tablets in this series have a gel inside. This form allows the active substance, Tadalafil, to immediately enter the blood, thus providing an immediate effect. The result from the Cialis Super Active tablets appears after 5 minutes! The action lasts for two days. The drug is safe and has virtually no contraindications.
The drug has a thymoleptic and anxiolytic effect. Prescribed for the treatment of depressions of various origins, enuresis including the night one.
Cardizem, derivative benzothiazepine, has anti-anginal, antiarrhytmic and hypotensive effect. It is prescribed at arterial hypertension: after myocardial infarction, at patients with accompanying stenocardia when beta adrenoblockers, are contraindicative at patients with diabetic nephropathy, in cases when ACE inhibitors are contraindicated; angina of effort, Prinzmetal's angina; prevention of a coronary spasm when carrying out a coronary angiography or operation of aortocoronary shunting.
Uroxatral - Alfuzosinis an active substance, as an antagonist of the α1 adenogenetic receptor, this drug relaxes the muscles of the prostate and the bladder. Used in the treatment of benign prostatic hyperplasia (BPH). Reduces pressure in the urethra and reduces resistance to urine flow, eases urination and eliminates dysuria.
Dostinex is used to treat hyperprolactinemia, which manifests as infertility, a violation of the menstrual cycle (oligomenorrhea, amenorrhea, anovulatory menstrual cycles), galactorrhea in women. Men use it to treat hyperprolactinemia, which manifests itself by a decrease in libido or impotence. The drug copes with micro- or macroprolactinoma, idiopathic hyperprolactinemia, syndrome of an empty Turkish saddle. It also suppresses physiological lactation after childbirth if the woman is unwilling or unable to breastfeed, or if there are contraindications to feeding for the child or the mother. The drug prevents lactation after childbirth in case of abortion or stillbirth.
