Prograf The active ingredient of the drug (Tacrolimus) binds to cytosolic protein (FKBP12), responsible for the intracellular accumulation of the drug. Designed for the prevention and treatment of allograft liver, kidneys and heart rejection reactions, including those resistant to standard immunosuppressive therapy regimes.
Prograf
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Prograf Product Description
Drug Uses
Prograf is an immunosuppressant, which inhibits formation of cytotoxic lymphocytes, responsible for graft rejection. Immunosuppressant Prograf controls the body's immune response to transplantation of a new organ and reduces the risk of the transplant rejection.
Prograf is prescribed to adults and elderly patients to prevent graft rejection of allogeneic liver, kidney and/or heart. This immunosuppressant can be administered to both adults and pediatric patients.
Children aged from 4 months to 18 years can be prescribed with Prograf only to prevent liver transplant rejection. Prograf efficacy in preventing rejection of kidney and heart transplant in pediatric patients has not been proven.
The dose of immunosuppressant Prograf should be matched based on the clinical assessment of the risk of rejection, the patient’s individual tolerance and body weight. The recommended dose of immunosuppressant Prograf for adults may vary from 0.075 mg to 0.2 mg per kg of body weight per day. Prograf daily dose for infants and children with a liver transplant may vary from 0.15 mg to 0.20 mg per kg of body weight.
Missed dose
If over 6 hours have passed after the missed intake of Prograf, then skip the missed dose. Do not double a dose and do not take extra immunosuppressants to make up for the missed dose of Prograf.
More Information
Like other immunosuppressants, Prograf is characterized by high nephrotoxic potential. Therefore, regular monitoring of renal function is recommended during the immunosuppressant therapy.
Storage
Immunosuppressant Prograf should be stored in its original package at controlled room temperature below 30°C.
Prograf Safety Information
Warnings
The patients taking Prograf are considered to be at risk because of long-term use of the immunosuppressant. In long-term application of Prograf, the risk for malignancies, particularly, skin lymphoma is increased. To reduce the risk for developing lymphoma, the patients are recommended to avoid long-term exposure to sunlight and being outdoors in direct sunlight too long uncovered by clothing.
Disclaimer
Information about prevention of organ rejection, described in this review of Prograf, is provided solely as general information. This information cannot be relied as a substitute for medical advice of the transplant doctor, surgeon or other health specialist. The online pharmacy assumes no responsibility for any loss suffered by the use or misuse of information on organ rejection and Prograf.
Prograf Side Effects
Prograf may cause in the patients having kidney transplant: infection, tremor, high blood pressure, abnormal renal function, constipation, vomiting, diarrhea, headache, abdominal pain, insomnia, nausea, urinary tract infection, leucopenia, asthenia, pain or anaemia.The patients, who underwent liver or heart transplantation, may experience during the immunosuppressant therapy: paraesthesia, leukocytosis, high blood sugar, high potassium, diabetes, itch or abnormalities of magnesium levels.
Combivir - the antiviral combined medicine. Lamivudin and zidovudine are highly effective selective inhibitors of HIV-1 and HIV-2. Lamivudin is a synergist of a zidovudine concerning oppression of replication of HIV.
Cialis Soft Tabs differs from a usual tablet of Cialis in the fact that its action comes quicker. Cialis Soft is chewed and dissolved under a tongue that allows to reach a required effect in 10-15 minutes. Important!!! Cialis Soft is compatible to alcohol and greasy food!
Brand Cialis improves erection and helps to achieve a successful sexual intercourse. It is the original medication, intended for use in adult men, who have problems with achieving and maintaining an erection. The pills start acting in 30 to 60 minutes. You can benefit from their effects for up to 36 hours. Therefore, you can take the pills on Saturday evening and enjoy a wonderful weekend, full of sex and pleasant emotions both for you and your partner. The active substance is Tadalafil.
Glycomet is a drug that is also called Biguanide. It’s a hypoglycemic agent that reduces the concentration of glucose in the blood by suppressing gluconeogenesis in the liver, reducing the absorption of glucose from the digestive tract, and increasing its utilization in tissues in patients with diabetes mellitus. The drug reduces the concentration of Thyroglobulin, cholesterol, and LDL (determined on an empty stomach) in the blood serum and does not change the concentration of lipoproteins of other densities. Glycomet stabilizes or reduces body weight. The pills don’t cause hypoglycemic reactions and improve the fibrinolytic properties of the blood.
Grifulvin V - the antifungal antibiotic, which is taken at mycoses of skin, hair and nails, and effective concerning fungus of the sort Trichophyton, Microsporum, Epydermophyton, Achorionum; causes disturbance of structure of mitotic spindle and synthesis of a cell wall in chitin fungus, suppresses division of fungal cells in metaphase and synthesis of protein because of disruption of linking with template-RNA.
Keflex – It is used for the treatment of infections of the upper respiratory tract, urogenital system, ENT organs, skin and soft tissues, bones and joints. Refers to a group of cephalosporin antibiotics of the first generation. It has an bactericidal effect, disrupts the synthesis of the cell wall of microorganisms. It is resistant enough to penicillinases of gram-positive microorganisms, It can be destroyed by beta-lactamases of gram-negative microorganisms.
Cleocin has bacteriostatic and bactericidal activity depending on concentration of drug, infectious process and condition of an organism of the patient. Active against aerobic and anaerobic streptococcus (except for enterococci), the majority of staphylococcus except for methicillin-resistant strains, bacteroids except for Bacteroides melaninogenicus, spindle-shaped bacteria
Isoptin is a calcium ion antagonist of the phenylalkylamine group. It improves myocardial perfusion, eliminates coronary spasm, reduces myocardial oxygen demand. It is used for diseases of the cardiovascular system.
Cardioselective beta-1 blocker. Does not have a membrane-stabilizing action and does not have an internal AGR. Has antihypertensive, anti-angiogenic and antiarrhythmic action. It is used for IHD, angina pectoris, unstable angina, myocardial infarction, arterial hypertension, hypertensive crisis, tachycardia, thyrotoxicosis.
Adalat, which is nifedipine - belongs to hypotensive medicine with antianginalny activity. Blocking calcic channels, an active component of Adalat (nifedipine) causes decrease in intracellular concentration of ions of calcium in smooth muscle cell of intima of vessels and cardiocyte, causing vasodilatory action - in particular, on coronary vessels. As a result of decreases systolic blood pressure, falls TPR and decreases afterload on cardiac muscle. Except for normalization of a coronary blood flow, Adalat promotes pressure decrease in system of pulmonary artery, improves cerebral haemo dynamics. Long-term taking of medicine guarantees anti-atherogenous action, prevents thrombocyte aggregation.
Silagra tablets do a highly effective job of relaxing the musculature in the phallus. The drug increases the movement of blood in caverns of the erectile tissue by vasodilatory activity. It belongs to the category of medicines distributed as PDE5 blockers. Similarly to Viagra, these pills contain sildenafil citrate – a substance that mainly finds use as a cure for erectile disorders. Silagra mainly interacts with the circulatory function and requires an adequate sexual stimulation to set in action. Its effect can be felt in 30-40 minutes, resulting in about 4 hours of strong erection.
Levitra Soft - convenient chewable tablets, also act as their famous analogue - Brand Levitra, but cost several times cheaper. This form of generic tablet has a pleasant taste, it does not need to be taken with water. The effect occurs maximum in 15 minutes after taking the drug and lasts about 12 hours. The tablet can be combined with alcohol and fatty foods. The number of side effects is minimal and they are manifested only in cases of an overdose.
Inhibitor of H+-K+-ATP, the dextrorotatory isomer of omeprazole. Reduces the secretion of hydrochloric acid in the stomach by specific inhibition of the proton pump in parietal cells. The therapeutic use includes gastroesophageal reflux disease: erosive reflux esophagitis (treatment), prevention of relapse in patients with healed esophagitis, symptomatic treatment of GERD.
Diamox weak diuretic which is taken at edematous syndrome, craniocereberal hypertensia, glaucoma, epilepsy and mountain disease. Inhibits carbonic anhydrase in a proximal gyrose tubule of nephron, increases removal with urine Na+, K+, hydrocarbonate, does not influence Cl- egestion, alkalinizes urine.
Dilantin - antiepileptic drug without the expressed somnolent effect; it has membrane stabilizing, antiarrhytmic and hypotensive effect. It is taken if it is diagnosed activated epilepsy, supraventricular and ventricular disturbances of a heart rhythm caused by intoxication cardiac glycosides.
Proscar - the drug is used to treat men’s baldness and benign prostatic hyperplasia. Inhibits the 5-alpha-reductase which converts testosterone into a more active 5-alpha-dihydrotestosterone, reduces its concentration in blood and prostate tissue.
Dutas is a mix of two medicines: dutasteride and tamsulosin hydrochloride. The drugs have complementary mechanisms of action, due to which there is a rapid weakening of urination. It reduces the risk of retention of the urine. It is not anticipated that the pharmacodynamic reactions of a fixed dosage mix of dutasteride-tamsulosin differ from those obtained with the simultaneous use of dutasteride and tamsulosin as separate elements. Dutasteride inhibits the activity of both the 1st and 2nd type of isoenzymes. DHT is an androgen that is responsible for prostate and the increase of BPH. It inhibits the activity of adrenoreceptors.
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Methotrexate belongs to the group of antimetabolites with cytostatic activity. It inhibits the conversion of dihydrofolic acid into tetrahydrofolic acid. Thymidylic acid and purine synthesis are disrupted, which, in turn, suppresses DNA synthesis and cell division. The maximum absorption of the medicine is observed after 30 to 60 minutes. The drug is metabolized by enzymes of the intestinal microflora, hepatocytes, and other cells.
Toradol - tablets containing 5 and 10 mg of ketorolac tromethamine as an active substance. It has a pronounced analgesic, as well as antipyretic and anti-inflammatory action, the mechanism of which is associated with inhibition of the synthesis of prostaglandins. Suppresses the aggregation of platelets.
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Doryx MPC (doxycycline hyclate) delayed-release tablets for oral use, contain doxycycline hyclate, a tetracycline class drug synthetically derived from oxytetracycline, in a delayed-release formulation consisting of pellets with a modified polymer enteric coat that has increased acid resistance.