Promethazine reduces the permeability of capillaries, swelling of the mucous membranes, itching. Has adrenolytic, moderate peripheral and central cholinolytic action. Inhibits histamine-N-methyltransferase, blocks central histamine H3 receptors. Oppresses the central nervous system, has a sedative, anxiolytic, antipsychotic and hypnotic effect, lowers body temperature. Reduces the excitability of the vestibular receptors, eliminates dizziness. Has antiemetic effect.
Promethazine
| Package | pill | Total price | Save | Order |
|---|---|---|---|---|
| 25mg × 60 Pills | $0.74 | $44.15 + Bonus - 4 Pills | - | Add to cart |
| 25mg × 90 Pills | $0.69 | $62.25 + Bonus - 7 Pills | $4.50 | Add to cart |
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Product Description
Promethazine - causes sedative effect, has antiemetic effect. It has also pronounced to be an adrenoblocking remedy, which moderates peripheral and central anticholinergic action. The effect starts already in 20 minutes after ingestion and lasts up to 6 hours, sometimes up to 12 hours.
The drug is used to cure some allergic diseases and reactions such as: rash, itching, eczema, drug rash, serum sickness, Quincke's edema, hay fever, anaphylactic shock, bronchial obstructive syndrome (as part of complex therapy).
Also it is prescribed for the treatment of skin diseases (including eczema, neurodermatitis, diathesis, contact dermatitis and toxicodermia).
Safety information
When administered orally for adults, the daily dose of the drug is 75-100 mg.
Maximum dosage: during oral administration, single dose - 75 mg, daily - 500 mg; It is used in the composition of lytic mixtures.
Children of 1 - 2 years take 5-10 mg 1-2 times a day; from 2 - 5 years - 5-10 mg 1-3 times a day; From 5 - 10 years - 5-15 mg 1-3 times a day; Older than 10 years and adolescents take 5-20 mg of Promethazine 1-3 times a day. In case of emergency (asthmatic status, false cereal), the dose may be increased to 1-2 mg / kg.
Contraindications:
- simultaneous use of MAO inhibitors,
- coma (including on the background of alcohol intoxication),
- severe disorders of the liver function,
- first trimester of pregnancy,
- lactation (breastfeeding),
- early childhood (2 months),
- hypersensitivity to promethazine or other phenothiazine derivatives.
Side effects
- Moderately expressed numbness of the oral mucosa, dry mouth, nausea, constipation, diarrhea, unpleasant sensations; Rarely - jaundice.
- Drowsiness, dizziness, anxiety, lethargy, fatigue, impaired coordination of movements, impaired vision; Rarely - tinnitus, euphoria, nervousness, insomnia, seizures, oculogic crisis, catatonic status, hysteria, psychomotor agitation, extrapyramidal disorders, headache, nystagmus.
- Tachycardia, bradycardia, palpitation, fainting, arterial hypotension (with iv introduction), arrhythmias.
- Contact dermatitis, photosensitivity, urticaria.
- Leukopenia, agranulocytosis, aplastic anemia, thrombocytopenic purpura.
- Exanthema, urticaria, angioedema, anaphylactic reactions.
- Irregular breathing, urinary retention.
A lipid-lowering agent. Reversibly inhibits HMG-COA reductase, inhibits the cholesterol synthesis at the stage of mevinolinic acid and moderately reduces its intracellular concentration. The indications for the drug use include: primary hypercholesterolemia mainly of IIa and IIb types, under the ineffective diet treatment in patients with increased risk of coronary atherosclerosis, hypercholesterolemia combined with hypertriglyceridemia; prevention of coronary artery disease. The drug decreases the risk of myocardial infarction, the need for revascularization of the myocardium, deaths from cardiovascular system diseases.
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Albenza - anthelmintic agent which is active concerning adult individuals and larval forms. Albendazole influences polymerization of β-tubulin, which stops it. As a result, occurs violation of formation of microtubules in intestines of helminths, the ability of vermis to acquire glucose is suppressed. It is blocked the normal intracellular migration of organellas, and it is prevented the synthesis of ATP in their muscular tissue. Creation of therapeutic concentration of albendaloze leads to death of helminths. Medicine causes death of nematodes (Necator americanus, Strongyloides stercoralis, Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Cutaneous Larva Migrans, Ancylostoma duodenale), cestode (pig, bull and dwarf tapeworm), trematode (Clonorchis sinensis, Opisthorchis viverrini), elementary (Lamblia).
Gastroprotective agent, a synthetic analog of PgE1 boosts the formation of defensive slime and bicarbonate; enhances blood flow in the mucosa. It stimulates the healing of erosions, gastric and duodenal ulcers and is able to prevent their formation in some cases. It has a direct impact on the parietal cells of the abdomen, inhibits the lowest, and stimulated (by meal,pentagastrin, histamine) excretion of HCl. he drug diminishes the basal production of pepsin. The expected result occurs after 30 minutes and lasts at least 3-6 hours.
Gasex arranges the work of the intestine and reduces the time of digestion process. The drug acts as spasmolytic, antiulcerant, anti-inflammatory agent, cholagogue, hepatoprotective agent, membrane-modulating agent, an antimicrobial agent, and antioxidant. The drug also improves the digestibility of vitamins. It’s used for symptomatic control and relief of dyspepsia (upset stomach). The drug is used in case of flatulence, bloating, belching and for preliminary radiographic preparation of the intestine for radiography. The pills cope with discomfort in the abdomen in the postoperative period or during prolonged immobilization.
Peripheral vasodilator with predominant effect on venous vessels. Reduces the need for myocardium in oxygen by reducing preload and afterload (reduces the end diastolic volume of the LV and reduces the systolic tension of its walls). Has the coronary dilatation effect. Reduces blood flow to the right atrium, helps to reduce pressure in the "small" circle of blood circulation and regression of symptoms with pulmonary edema. Promotes redistribution of coronary blood flow in the area with reduced blood circulation. Increases tolerance to physical activity in patients with IHD, angina pectoris.
Voltaren Gel is an over the counter and prescription medicine used to treat symptoms of actinic keratosis, osteoarthritis, acute pain and arthritis pain. Voltaren Gel may be used alone or with other medications.
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